Mutations in the Fas Antigen in Patients With Multiple Myeloma
نویسندگان
چکیده
منابع مشابه
Mutations in the Fas antigen in patients with multiple myeloma.
Programmed cell death, or apoptosis, is well documented as a physiological means of eliminating activated lymphocytes and maintaining immune homeostasis. Apoptosis has also been implicated in the targeting of tumor cells by cytotoxic T lymphocytes and natural killer cells. One of the two primary mechanisms used in cell-mediated cytotoxicity is the Fas/FasLigand system. Activated or transformed ...
متن کاملRAPID COMMUNICATION Mutations in the Fas Antigen in Patients With Multiple Myeloma
Programmed cell death, or apoptosis, is well documented as eloma. Using reverse transcriptase-polymerase chain reaca physiological means of eliminating activated lymphocytes tion (RT-PCR), single-stranded conformation polymorphism and maintaining immune homeostasis. Apoptosis has also (SSCP) analysis, and DNA sequencing, we examined the been implicated in the targeting of tumor cells by cytotox...
متن کاملFrequency of FLT3 ITD and FLT3 TKD Mutations in Multiple Myeloma Patients (A Case Control Study)
Background and Aims: Multiple myeloma is a malignant proliferation of plasma cells derived from a single clone. The tumor, its products and the host response lead to organ damages. Some factors that are responsible in its pathogenesis are recognized. As FMS like Tyrosine Kinase 3 receptor (FLT3) mutation has been proved as a determining factor in leukemic patients the goal of this study was to ...
متن کاملthe past hospitalization and its association with suicide attempts and ideation in patients with mdd and comparison with bmd (depressed type) group
چکیده ندارد.
p53 mutations in multiple myeloma.
Correspondence p53 gene mutations in multiple myeloma We were interested in the article by Owen et al on p53 gene mutations in multiple myeloma.' They had studied the p53 exons 5-9 by PCR-SSCP and they found only one p53 mutation among 36 DNA samples from 31 patients with multiple myeloma. They concluded that p53 mutations are rare and confined to end stage leukaemic forms of the disease. We al...
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ژورنال
عنوان ژورنال: Blood
سال: 1997
ISSN: 1528-0020,0006-4971
DOI: 10.1182/blood.v90.11.4266